THOMAS FITZ-HUGH JR., A.M., M.D., F.A.C.P.
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The designation, agranulocytic angina, although etymologically incorrect and scientifically inept, has become firmly entrenched—despite other preferable designations such as "pernicious leukopenia" or "primary granulocytopenia." It is here employed, in the now generally accepted sense, as designating the syndrome of Schultz. This disorder was at first viewed as a peculiar reaction to some unknown infection, analogous to the previously recognized leukopenia sometimes encountered in overwhelming sepsis. Soon, however, it became clear that the heterogeneous microorganismal invasion, seen in the majority of cases of agranulocytic angina, is merely a secondary or terminal event and is preceded by profound neutropenia. This led to
FITZ-HUGH T. DRUG IDIOSYNCRASY, WITH SPECIAL REFERENCE TO AMIDOPYRINE, AS A CAUSE OF AGRANULOCYTIC ANGINA*. Ann Intern Med. 1934;8:148–155. doi: https://doi.org/10.7326/0003-4819-8-2-148
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Published: Ann Intern Med. 1934;8(2):148-155.
Cardiology, Coronary Heart Disease.
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