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In the past few years the rôle of the so-called "circulatory hormones" has been an interesting and ever changing one. The first circulatory hormone was described in 1926 by Frey and Kraut.1 They isolated a substance from urine which, on intravenous injection into dogs, caused a fall in the blood pressure (in the systolic more than in the diastolic) and an increase in the amplitude of the heart contractions. This substance was called "kallikrein," later "padutin." They observed the same active substance in the blood except that it occurred in an inactivated form and had to be especially treated to
THE SO-CALLED "CIRCULATORY HORMONES". Ann Intern Med. ;8:509–511. doi: 10.7326/0003-4819-8-4-509
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Published: Ann Intern Med. 1934;8(4):509-511.
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