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Within the past decade a new concept of the method of transmission of the effects of nerve impulses has developed. Dale recently has summarized the contributions and development of knowledge in this field. The first suggestion that a chemical agent acted as an intermediary between nerve stimulation and effector response was made by Elliot in 1904. After noting the similarity between the action of epinephrine and the stimulation of sympathetic nerves, he postulated that sympathetic nerve fibers liberated epinephrine at their endings; the epinephrine, he implied, might be the chemical intermediary between nerve impulse and effector response. Dixon was the
CHEMICAL FACTORS IN THE BEHAVIOR OF THE VEGETATIVE NERVOUS SYSTEM. Ann Intern Med. ;8:648–650. doi: 10.7326/0003-4819-8-5-648
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Published: Ann Intern Med. 1934;8(5):648-650.
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