JOSEPH R. DARNALL, M.D., F.A.C.P.
Hemochromatosis, as the name indicates, is a metabolic disorder characterized by the deposition of the blood pigments hemofuscin and hemosiderin in various organs and tissues, associated with progressive interstitial fibrosis and sclerosis of the organs subjected to the abnormal deposition of pigment, particularly the liver, pancreas and spleen.
In a large proportion of cases (85 per cent according to an analysis of 53 cases by Blanton and Healy4) the disease is accompanied, especially in its later stages, by diabetes mellitus. Most patients show a definite increase in pigmentation of the skin, due to hemosiderin and often associated with increase in
DARNALL JR. HEMOCHROMATOSIS: REVIEW OF THE LITERATURE AND REPORT OF THREE CASES*. Ann Intern Med. 1935;8:1121–1137. doi: https://doi.org/10.7326/0003-4819-8-9-1121
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Published: Ann Intern Med. 1935;8(9):1121-1137.
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