WILLIAM S. MIDDLETON, F.A.C.P.; OVID O. MEYER
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By reason of its wide dispersion through the body the bone marrow is not ordinarily viewed as an integral organ; yet such it is, and an extremely interesting and important one in the light of its manifold functions. Its hematopoietic activity in the formation of erythrocytes, leukocytes and thrombocytes is generally appreciated; but its wealth of reticulo-endothelium determines certain further functions that are less widely understood. Bile pigment is formed in great amounts in the marrow. Antibodies are likewise developed through reticulo-endothelial activity. However, particular attention in the present relation is directed toward the commoner cellular elements of the circulating
MIDDLETON WS, MEYER OO. MARROW INSUFFICIENCY1. Ann Intern Med. 1935;8:1575–1590. doi: 10.7326/0003-4819-8-12-1575
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Published: Ann Intern Med. 1935;8(12):1575-1590.
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