GRACE A. GOLDSMITH, M.D.
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Choline and its compounds have been investigated extensively in recent years. Acetylcholine was first prepared by Baeyer in 1867 but remained of chemical interest only until Hunt and Taveau in 1906 noted its marked physiologic activity. Both choline and acetylcholine have been isolated from animal tissues, Dale obtaining the latter in pure chemical form in 1929. Acetylcholine owes its present importance to the almost certain proof that it is the chemical intermediary between parasympathetic nerve stimulation and tissue response (Dale and Alles).
Acetylcholine has three important actions: (1) a parasympathetic effect, inhibiting cardiac action and increasing intestinal tonus; (2) a
GOLDSMITH GA. THE EFFECTIVENESS OF ACETYL-B-METHYLCHOLINE GIVEN BY MOUTH AS A VASODILATING AGENT*. Ann Intern Med. 1936;9:1196–1202. doi: https://doi.org/10.7326/0003-4819-9-9-1196
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Published: Ann Intern Med. 1936;9(9):1196-1202.
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