FREDERICK KELLOGG, M.D.; NORMAN N. EPSTEIN, M.D.; WM. J. KERR, M.D., F.A.C.P.
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Hepatitis as a complication of anti-syphilitic therapy is not an uncommon occurrence. The injury thus suffered by the liver may be transient or it may be permanent, resulting in cirrhosis. Thus Baldridge1 reported that, of a series of 36 patients with definite portal cirrhosis, one-third had histories of treatment for syphilis. During the past 10 years the value of controlling the arsphenamine treatment of syphilis by functional tests of the liver has been repeatedly emphasized. Such tests are indicated especially for patients with histories of hepatic disease or with evidence of disturbance of the liver developing during the course of
KELLOGG F, EPSTEIN NN, KERR WJ. HEPATIC COMPLICATIONS IN THE TREATMENT OF SYPHILIS: II. INCIDENCE OF HEPATIC DISEASE IN PATIENTS WITH UNTREATED SYPHILIS AND DURING THEIR SUBSEQUENT TREATMENT1. Ann Intern Med. ;9:1561–1571. doi: 10.7326/0003-4819-9-11-1561
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Published: Ann Intern Med. 1936;9(11):1561-1571.
Gastroenterology/Hepatology, Infectious Disease, Liver Disease, Sexually Transmitted Infections.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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