GEORGE M. LEWIS, M.D.; WILBERT SACHS, M.D.
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The origin and nature of the xanthoma cell is in doubt.1 Because of this, its significance is not fully understood. Many observers have noted the rather widespread occurrence of xanthoma-like cells in dermatoses not usually considered among the true xanthomas. In using the term fibroxanthoma, a combination of a fibroma with a xanthoma is implied. Aschoff and Kammer2 consider that such a unification exists and classify fibroxanthoma as a type of the true xanthomas. Pinkus and Pick2 contend that the process is more likely due to the ability of tumors of the connective tissue group to become enriched with lipoids.
LEWIS GM, SACHS W. LIPOIDAL HISTIOCYTOMA (FIBROXANTHOMA); REPORT OF A CASE*. Ann Intern Med. 1936;9:1746–1750. doi: https://doi.org/10.7326/0003-4819-9-12-1746
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Published: Ann Intern Med. 1936;9(12):1746-1750.
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