EVERETT B. POOLE, M.D.
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The disease which has been called fragilitas ossium, Lobstein's disease,1 or osteopsathyrosis is characterized by the remarkable symptomatic triad of blue sclerae, brittle bones, and deafness. The general features of the disease have been well summarized by Apert,2 and by Ottley,3 who give comprehensive reviews of the literature. Ottley lists the following as characterizing the syndrome of osteopsathyrosis:
1. Fragility of bone.
2. Peculiar conformation and structure of bone.
3. Peculiar shape of the skull.
4. Laxity of the ligaments.
5. Blue coloration of the sclerae.
7. Abnormal electrical reaction of the muscles.
8. Miscellaneous abnormalities of the
POOLE EB. AN UNUSUAL CASE OF OSTEOPSATHYROSIS (FRAGILITAS OSSIUM, LOBSTEIN'S DISEASE)1. Ann Intern Med. ;10:683–688. doi: 10.7326/0003-4819-10-5-683
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Published: Ann Intern Med. 1936;10(5):683-688.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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