G. E. WAKERLIN, M.D., Ph.D., F.A.C.P.
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The hemopoietic liver principle is also known as the anti-pernicious anemia principle and the erythrogenic liver principle. As you are aware, the interaction in the gastrointestinal tract of an as yet unidentified constituent of the gastric juice, called the "intrinsic factor," with some dietary component associated with protein, known as the "extrinsic factor," forms a third substance which is absorbed via the portal circulation and stored in the liver where it is very likely further elaborated. This substance, the hemopoietic liver principle, is then released to the bone marrow where it brings about the normal maturation of the red blood
WAKERLIN GE. THE HEMOPOIETIC LIVER PRINCIPLE*. Ann Intern Med. 1937;11:31–38. doi: https://doi.org/10.7326/0003-4819-11-1-31
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Published: Ann Intern Med. 1937;11(1):31-38.
Gastroenterology/Hepatology, Liver Disease.
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