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It has been observed frequently that the blood of patients with lymphosarcoma may become leukemic. This syndrome has been characterized as leukosarcoma by Sternberg1 or as lymphosarcoma terminating in lymphatic leukemia.2, 3, 4 Flashman and Leopold5 noted 107 cases of this type in the literature and described an additional case. On the basis of a lymphosarcoma presumably terminating in lymphatic leukemia, numerous speculations have been published concerning the relationship of these two conditions. A careful cytological study of the cell types in this form of leukemia has shown, however, that the cells are not lymphocytes, but lymphosarcoma cells, so that
ISAACS R. AN ARTICLE CONTRIBUTED TO AN ANNIVERSARY VOLUME IN HONOR OF DOCTOR JOSEPH HERSEY PRATT: LYMPHOSARCOMA CELL LEUKEMIA*. Ann Intern Med. 1937;11:657–662. doi: https://doi.org/10.7326/0003-4819-11-4-657
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Published: Ann Intern Med. 1937;11(4):657-662.
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