HENRY T. RICKETTS, M.D.
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The efficacy of protamine insulin in the treatment of diabetes has been convincingly demonstrated by a number of workers2, 3, 6, 9, 11, 12, 13, 14, 15, 18, 19 during the past year. Its superiority over the old insulin as evidenced by better control of the blood sugar, fewer reactions, reduction in the number of daily injections and often an appreciable saving in total requirement cannot be doubted.
All investigators† have recognized, however, that the slow and prolonged action to which protamine insulin owes its conspicuous advantages is also responsible for certain difficulties peculiar to its use. Its seems appropriate
RICKETTS HT. PROBLEMS CONNECTED WITH THE USE OF PROTAMINE-ZINC-INSULIN*. Ann Intern Med. 1937;11:777–790. doi: https://doi.org/10.7326/0003-4819-11-5-777
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Published: Ann Intern Med. 1937;11(5):777-790.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism, Hospital Medicine.
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