HAROLD JEGHERS, M.D.; HENRY J. BAKST, M.D.
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Azotemia signifies an abnormal increase in the non-protein nitrogen (NPN) level of the blood. Normally the blood of a fasting person contains from 25 to 35 mg. per cent of non-protein nitrogen; this includes urea, uric acid, ammonia, amino acid, creatine, creatinine and some nitrogenous substances known as undetermined nitrogen or rest nitrogen. Values for blood non-protein nitrogen over 40 mg. per 100 c.c. are considered abnormal.
Theoretically an azotemia could be caused by an increase of any of these non-protein nitrogen constituents. The amounts of uric acid, ammonia, creatine and creatinine are so small that increases of even several
JEGHERS H, BAKST HJ. THE SYNDROME OF EXTRARENAL AZOTEMIA*. Ann Intern Med. 1938;11:1861–1899. doi: https://doi.org/10.7326/0003-4819-11-10-1861
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Published: Ann Intern Med. 1938;11(10):1861-1899.
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