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Organic mercurial compounds have been recognized as having valuable diuretic properties since 19201 and have been used with increasing frequency since the introduction of salyrgan in 1924.2 Later mercupurin (novurit), neptal and mercurosal were used. These drugs proved to be of great benefit in the treatment of cardiac edema, of moderate assistance in the management of nephrotic edema, and of lesser therapeutic value in the edema and ascites of hepatic cirrhosis. In addition to the known limitations, the drugs were objectionable because they were mercurials and thus renal irritants. Great care was therefore necessary in controlling their administration to
THE USE OF THE MERCURIAL SUPPOSITORY AS A DIURETIC1. Ann Intern Med. 1938;11:1962–1972. doi: 10.1059/0003-4819-11-11-1962
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Published: Ann Intern Med. 1938;11(11):1962-1972.
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