H. CLARE SHEPARDSON, M.D., F.A.C.P.; RICHARD DUFFICY FRIEDLANDER, M.D.
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Since the publication of Hagedorn's article1 on protamine insulinate in January 1936, followed by the substitution of protamine zinc insulin for protamine insulinate as the result of the work of Scott and Fisher2 and the introduction of a new crystalline insulin by Sahyun of Detroit, medical periodicals have been flooded with reports concerning the treatment of diabetes mellitus with these new long-acting insulins.
To review this literature would be superfluous indeed, since it has been adequately summarized in numerous previous articles. The reader interested in a comprehensive survey of the literature on this subject is referred to the papers of
SHEPARDSON HC, FRIEDLANDER RD. CLINICAL EXPERIENCES WITH LONG-ACTING INSULIN IN AMBULATORY DIABETIC PATIENTS1. Ann Intern Med. 1938;12:830–837. doi: 10.7326/0003-4819-12-6-830
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Published: Ann Intern Med. 1938;12(6):830-837.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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