CYRUS C. STURGIS, M.D., F.A.C.P.; S. MILTON GOLDHAMER, M.D.
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A macrocytic anemia may be defined as an anemia in which there is an increase in the number of red blood cells of the circulating blood having a diameter greater than 7.5 microns, and a mean corpuscular volume which exceeds 96 cubic microns. In such an anemia the color index usually is one or higher. It is generally considered to be due to defective blood formation and is frequently controlled by anti-pernicious anemia medication but is not ordinarily benefited by iron therapy.
An anemia of this type is characteristically found in true Addisonian pernicious anemia, in the so-called "tropical anemia"
STURGIS CC, GOLDHAMER SM. MACROCYTIC ANEMIA, OTHER THAN PERNICIOUS ANEMIA, ASSOCIATED WITH LESIONS OF THE GASTROINTESTINAL TRACT1. Ann Intern Med. 1939;12:1245–1262. doi: 10.7326/0003-4819-12-8-1245
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Published: Ann Intern Med. 1939;12(8):1245-1262.
Gastroenterology/Hepatology, Hematology/Oncology, Red Cell Disorders.
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