C. W. SCULL, Ph.D.; T. F. BACH, M.D., F.A.C.P.; RALPH PEMBERTON, M.D., F.A.C.P.
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Chronic arthritics present a variety of symptoms which involve deviations from normal protein metabolism.1 This is graphically evident in gout, one of the smaller groups of rheumatoid disease, which is characterized by the accumulation of urates in articular and other tissues. This local feature is associated with systemic evidence of an abnormal metabolism of nucleo-protein. The absence of this conspicuous feature in the other and larger groups of rheumatoid disease has diverted attention from a consideration of such deviations in protein metabolism as are presented by them. These deviations include both local and systemic features. One large group, namely
SCULL CW, BACH TF, PEMBERTON R. SERUM PROTEINS IN RHEUMATOID DISEASE1. Ann Intern Med. ;12:1463–1472. doi: 10.7326/0003-4819-12-9-1463
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Published: Ann Intern Med. 1939;12(9):1463-1472.
Rheumatoid Arthritis, Rheumatology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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