BEN FRIEDMAN; MYRON PRINZMETAL
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Recent investigations have suggested that the abnormal vasoconstriction in animals and patients with persistent hypertension is due to a non-nervous and presumably chemical mechanism.1, 2, 3, 4, 5 Increased amounts of a pressor substance have been demonstrated in saline extracts made from kidneys of dogs with renal hypertension and from kidneys of patients suffering from hypertensive disease.6, 7 These observations are compatible with the hypothesis that such forms of hypertension are due to the humoral accumulation of a pressor substance of renal origin. This hypothesis would be verified by the demonstration of increased amounts of the substance in the blood
FRIEDMAN B, PRINZMETAL M. VASOMOTOR EFFECTS OF BLOOD IN PATIENTS WITH HYPERTENSION AND ANIMALS WITH EXPERIMENTAL HYPERTENSION1. Ann Intern Med. 1939;12:1617–1631. doi: 10.7326/0003-4819-12-10-1617
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Published: Ann Intern Med. 1939;12(10):1617-1631.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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