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The exact anatomical location of lesions which will cause diabetes insipidus has long been a controversial matter from both a clinical and experimental viewpoint. The excellent work of Fisher, Ingram, and Ranson definitely localizes such lesions to the supra-optic-hypophyseal system. The authors further demonstrate that the symptoms of permanent polyuria and polydipsia will not appear unless there is normal anterior pituitary tissue present. Their experimental work is valuable for its careful histological examinations, the production of localized lesions, and the large series of animals used (cats and monkeys).
In the latter part of the book the authors review the literature
Diabetes Insipidus.. Ann Intern Med. ;12:1723. doi: 10.7326/0003-4819-12-10-1723
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Published: Ann Intern Med. 1939;12(10):1723.
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