JACKSON M. THOMAS, M.D.; ELVIN V. SEMRAD, M.D.; ROBERT S. SCHWAB, M.D.
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In 1915 Steinebach,1 reported that he observed remarkable improvement in 18 cases of delirium tremens immediately after lumbar puncture and withdrawal of cerebrospinal fluid. He thought that improvement resulted from the reduction of a high cerebrospinal pressure and a diminution of "toxic" elements circulating in the cerebrospinal fluid. Since Steinebach's first report appeared, the literature pertaining to the treatment of delirium tremens has contained other citations of the therapeutic efficacy of lumbar puncture in the treatment of this disorder (Hoppe,2 Goldsmith,3 and Ebaugh and Johnson4).
Assuming that an increase in cerebrospinal fluid pressure and edema play a significant rôle in
THOMAS JM, SEMRAD EV, SCHWAB RS. OBSERVATIONS ON THE USE OF FLUIDS AND LUMBAR PUNCTURE IN THE TREATMENT OF DELIRIUM TREMENS1. Ann Intern Med. 1939;12:2006–2009. doi: 10.7326/0003-4819-12-12-2006
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Published: Ann Intern Med. 1939;12(12):2006-2009.
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