HARRY SHAY, M.D.; J. GERSHON-COHEN, M.D., D.SCI. (MED.); SAMUEL S. FELS, LL.D.
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The prohibition in Leviticus†: "Ye shall eat no manner of fat, of ox, or of sheep, or of goat," might mean that the ancients were aware of the retardation of gastric digestion by fats. Certainly Aristotle, in his Problemata,‡ discussed the effect of fat upon digestion in the stomach with an assurance that indicated much observation and thought.
In 1886 Ewald and Boas1 demonstrated that fat in the upper digestive tract decreased gastric activity. Beaumont,2 too, had previously stressed the difficulty of digestion of oily foods. From Pavlov's laboratory, however, came the first experiments proving that fat diminished gastric secretion.
SHAY H, GERSHON-COHEN J, FELS SS. THE RÔLE OF THE UPPER SMALL INTESTINE IN THE CONTROL OF GASTRIC SECRETION; THE EFFECT OF NEUTRAL FAT, FATTY ACID, AND SOAPS; THE PHASE OF GASTRIC SECRETION INFLUENCED AND THE RELATIVE IMPORTANCE OF THE PSYCHIC AND CHEMICAL PHASES*. Ann Intern Med. 1939;13:294–307. doi: https://doi.org/10.7326/0003-4819-13-2-294
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Published: Ann Intern Med. 1939;13(2):294-307.
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