SOLOMON GINSBURG, M.D.
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More than a century and a half has now elapsed since Parry,1 in 1786, noted and described exophthalmos in the first classical case of exophthalmic goiter recorded in medical literature. Since then the problem of the etiology and pathogenesis of exophthalmos in association with thyroid disease has been the theme of numerous and intensive studies and investigations—clinical, pathologic and experimental. As the result of these studies, numerous theories of the pathogenesis of exophthalmos have been propounded (table 1), but a complete solution of the problem has not been reached. We have gained considerable knowledge when and how exophthalmos develops in
GINSBURG S. POSTOPERATIVE PROGRESSIVE EXOPHTHALMOS WITH LOW BASAL METABOLIC RATE*. Ann Intern Med. 1939;13:424–450. doi: https://doi.org/10.7326/0003-4819-13-3-424
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Published: Ann Intern Med. 1939;13(3):424-450.
Endocrine and Metabolism, Thyroid Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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