M. M. MILLER, M.D.; O. P. ALLEN, M.D.
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It has been said that insulin administration cannot be calculated by mathematical equations; that no one knows the exact amount of carbohydrate that will be metabolized by a given amount of insulin.1
Probably every physician of experience in the treatment of diabetes mellitus has been puzzled at times to know how much insulin a given patient requires. We have all been confronted with the widely varied responses of different patients, as well as of the same patient at different times, to comparable doses of insulin.
This dissimilarity of response of different patients to comparable doses, or of the same patient
MILLER MM, ALLEN OP. A NEW MATHEMATICAL METHOD FOR THE EVALUATION OF ENDOGENOUS INSULIN SECRETION*. Ann Intern Med. 1939;13:636–649. doi: https://doi.org/10.7326/0003-4819-13-4-636
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Published: Ann Intern Med. 1939;13(4):636-649.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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