JASON E. FARBER, M.D.
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Simmonds' disease or pituitary cachexia is a syndrome ascribed to destruction or physiological exhaustion of the hypophysis (chiefly the anterior portion). The destruction may be caused by embolic infarction, tumor, syphilis, tuberculosis, metastatic abscesses, inflammation, etc. Clinically the Simmonds' syndrome is characterized by cachexia, premature senility, atrophy of the gonads and genitalia, with amenorrhea, atrophy of the breasts, loss of pubic and axillary hair, loss of libido, integumental changes (chiefly dryness of the skin), anorexia and constipation, hypotension and muscular weakness, hypoglycemia, decreased sugar tolerance, lowered basal metabolism and depressed specific dynamic action of proteins, anemia, lymphocytosis and sometimes eosinophilia.
FARBER JE. SIMMONDS' DISEASE (PITUITARY CACHEXIA); REPORT OF A CASE*. Ann Intern Med. 1940;13:2171–2177. doi: https://doi.org/10.7326/0003-4819-13-11-2171
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Published: Ann Intern Med. 1940;13(11):2171-2177.
Endocrine and Metabolism, Neurology, Pituitary Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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