EMMET F. PEARSON, F.A.C.P.
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The focal reactions which result in the clinical syndromes of bronchial asthma, vasomotor rhinitis, eczema, urticaria and angioneurotic edema occur in tissue which is supplied by the cholinergic division of the autonomic nervous system. The peripheral mechanism which produces these symptoms may be initiated or exaggerated by different stimuli such as the antigen-antibody reaction of allergy, local irritation, infection, autonomic nervous reflex, and emotion or psychogenic stimuli. It is frequently possible to reproduce at will the particular symptom to which a hypersensitive individual is susceptible by small doses of acetylcholine or its derivatives. Hundreds of methods of altering the status
PEARSON EF. CLINICAL DESENSITIZATION TO WHEAT BY USE OF AN ACETYLCHOLINE DERIVATIVE1. Ann Intern Med. ;13:2241–2245. doi: 10.7326/0003-4819-13-12-2241
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Published: Ann Intern Med. 1940;13(12):2241-2245.
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