FRANCES F. BECK, PH.D.; RUTH MUSSER, M.S.; C. JELLEFF CARR, PH.D.; JOHN C. KRANTZ JR., PH.D.
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The problem of producing a substitute carbohydrate for dextrose in the treatment of diabetes has been studied extensively by various investigators. This subject was comprehensively reviewed by Gottschalk1 in 1929. Not any of the compounds studied has proved satisfactory from the point of view of being metabolized with a smaller amount of insulin than is dextrose. Moreover these compounds have defects as to availability, toxicity and taste. Perhaps the most promising substance studied for this purpose was dihydroxyacetone, investigated by Rabinowitch.2 The possible merits of this substance at present, at least, are off-set by the cost of manufacture and
BECK FF, MUSSER R, CARR CJ, KRANTZ JC. STUDIES IN THE METABOLISM OF DEXTROSE FRAGMENTS IN MAN1. Ann Intern Med. 1940;14:122–128. doi: 10.7326/0003-4819-14-1-122
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Published: Ann Intern Med. 1940;14(1):122-128.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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