ERICH UHLMANN, M.D.; ABRAHAM GROSSMAN, M.D.
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There has been profound change in our conception of the disease originally described by von Recklinghausen in 1882 in his article on "Fibrome der Haut." For many years the disease was looked upon as a disorder of the peripheral nerves alone, especially of the cutaneous filaments. Multiple soft nodules of the skin (molluscum fibrosum) and the subcutaneous neurofibromata so frequently associated with them were considered the main attributes of the clinical condition. By 1901 Adrian had collected 407 cases, in many of which pigmentary changes had either anteceded or were coexistent with the formation of neurofibromata. The recognition of allied
UHLMANN E, GROSSMAN A. VON RECKLINGHAUSEN'S NEUROFIBROMATOSIS WITH BONE MANIFESTATIONS1. Ann Intern Med. ;14:225–241. doi: 10.7326/0003-4819-14-2-225
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Published: Ann Intern Med. 1940;14(2):225-241.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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