GEORGE W. THORN, F.A.C.P.; KENDALL EMERSON JR.
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The occurrence of generalized edema, associated with menstruation has been reported by Thomas,1 Sweeney,2 Molnar and Gruber3 and Atkinson and Ivy.4 Experimentally it has been observed5 that the intramuscular injection of large doses of crystalline sex hormones (estrone, estradiol, testosterone and progesterone) in both male and female dogs resulted in a striking, but temporary, retention of sodium, chloride and water. Qualitative as well as quantitative differences were also noted in the effect of treatment with sex hormones on the renal excretion of potassium, phosphate and nitrogen.5
In a recent study6 it was noted that 24 of a
THORN GW, EMERSON K. THE RÔLE OF GONADAL AND ADRENAL CORTICAL HORMONES IN THE PRODUCTION OF EDEMA12. Ann Intern Med. ;14:757–769. doi: 10.7326/0003-4819-14-5-757
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Published: Ann Intern Med. 1940;14(5):757-769.
Endocrine and Metabolism, Hospital Medicine.
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