IRVINE H. PAGE
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Virchow was the first to recognize that atheromatosis might result from loosening of the connective tissue ground-substance, of which the arterial intima is for the most part composed, and subsequent infiltration with fat from the blood stream. The loosening of the ground-substance was believed to be caused by mechanical strain. Aschoff and Ribbert in particular have championed this so-called "infiltration theory."
Aschoff1 thought that the fatty material deposited in vessels consisted almost exclusively of cholesterol esters coming from blood plasma which nourished the vessel wall. He agreed with Virchow that those regions of the vessels which are under greatest mechanical
PAGE IH. SOME ASPECTS OF THE NATURE OF THE CHEMICAL CHANGES OCCURRING IN ATHEROMATOSIS*. Ann Intern Med. 1941;14:1741–1755. doi: https://doi.org/10.7326/0003-4819-14-10-1741
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Published: Ann Intern Med. 1941;14(10):1741-1755.
Cardiology, Coronary Risk Factors, Dyslipidemia.
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