JOSEPH EARLE MOORE, M.D.; HARRY EAGLE, M.D.
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The complement fixation reaction for the diagnosis of syphilis was introduced by Wassermann, Neisser, and Bruck in 1906; and the foundation of modern flocculation technics was laid by Michaelis in 1907. These originators used a fixed amount of patient's serum, a qualitative procedure still used in most serodiagnostic laboratories. The amounts of patient's serum used in the standard qualitative diagnostic tests commonly employed in the United States are shown in table 1. Because of the widely different types
of "antigen" suspension used in these tests, and because the serum: antigen ratio rather than the absolute amount of serum is the
MOORE JE, EAGLE H. THE QUANTITATIVE SEROLOGIC TEST FOR SYPHILIS; ITS VARIABILITY, USEFULNESS IN ROUTINE DIAGNOSIS, AND POSSIBLE SIGNIFICANCE; A STUDY OF 1665 CASES1. Ann Intern Med. ;14:1802–1814. doi: 10.7326/0003-4819-14-10-1802
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Published: Ann Intern Med. 1941;14(10):1802-1814.
Infectious Disease, Sexually Transmitted Infections.
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