HOWARD K. RATHBUN; JULIUS M. WAGHELSTEIN
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Weil,1 in 1886, described a disease characterized by jaundice and nephritis. Inada and his co-workers2 in a remarkable series of reports delineated the clinical and pathological picture, described the etiological agent and named it Spirochaeta icterohaemorrhagica. Noguchi,3 in 1917, reported the presence in American wild rats of a spirochete morphologically and immunologically identical with the Japanese and European strains. In 1918 he4 further described the organism and called it Leptospira icterohaemorrhagica. Wadsworth et al.5 described the first case in the United States which occurred as an accidental infection in a laboratory worker.
Noguchi4 described the causative organism as a very
RATHBUN HK, WAGHELSTEIN JM. WEIL'S DISEASE; REPORT OF SIX CASES1. Ann Intern Med. ;15:395–407. doi: 10.7326/0003-4819-15-3-395
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Published: Ann Intern Med. 1941;15(3):395-407.
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