ARTHUR C. CURTIS, M.D., F.A.C.P.; SIDNEY S. SOBIN, PH.D.
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Shortly after the introduction of sulfapyridine into clinical medicine, hematuria was described as one of the common and dangerous complications of this type of therapy. Acetylsulfapyridine was demonstrated as the excretory form of the drug,1, 2, 3 and the relationship between crystals of acetylsulfapyridine in the urine and hematuria was quickly recognized.4, 5, 6, 7, 8
This work was begun to record the solubility characteristics of acetylsulfapyridine and to determine the type and the amount of urine necessary to effect complete solution of this material. Our method was as follows: a portion of urine was concentrated to a specific gravity
CURTIS AC, SOBIN SS. THE SOLUBILITY OF ACETYLSULFAPYRIDINE AND ACETYLSULFATHIAZOLE IN THE URINE1. Ann Intern Med. ;15:884–889. doi: 10.7326/0003-4819-15-5-884
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Published: Ann Intern Med. 1941;15(5):884-889.
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