RALPH A. KINSELLA, F.A.C.P.
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The treatment of bacterial endocarditis by chemical agents has been under consideration for many years, and the literature before sulfanilamide contains many reports of cures.
The reproduction of the disease in dogs1, 2, 3 and its cure following the use of merthiolate intravenously4 and sulfanilamide orally4 created a hope that such agents could be successful in human cases. With the failure of merthiolate and the extended interest in the use of sulfonamide drugs in other fields of coccal infection, there has been renewed study of the use of these sulfonamide drugs in all forms of bacterial endocarditis.
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KINSELLA RA. CHEMOTHERAPY OF BACTERIAL ENDOCARDITIS1. Ann Intern Med. 1941;15:982–986. doi: 10.7326/0003-4819-15-6-982
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Published: Ann Intern Med. 1941;15(6):982-986.
Cardiology, Endocarditis, Infectious Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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