ROBERT HEILIG, M.D.; N. L. KANTIENGAR, B.SC., M.B.B.S.
While studying the excretion of hippuric acid in pregnancy Hirsheimer (1935) has shown that elimination of hippuric acid after administration of sodium benzoate is diminished towards the termination of normal and toxemic pregnancies, results confirmed later by other authors. The present investigation was undertaken to find whether the hepatic function during the menstrual period varies consistently from that recorded in the interval.
For this purpose we used Quick's test, based on the ability of the liver to detoxify benzoic acid by conjugation with glycine to form hippuric acid. First devised by Quick (1931), this test has been used sufficiently to
HEILIG R, KANTIENGAR NL. LIVER FUNCTION IN MENSTRUATION1. Ann Intern Med. ;16:538–546. doi: 10.7326/0003-4819-16-3-538
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Published: Ann Intern Med. 1942;16(3):538-546.
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