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Cases presenting the clinical syndrome later designated as lymphocytic choriomeningitis were first described by Wallgren (1935) under the term acute aseptic meningitis. These cases presented the picture of an acute febrile infection accompanied by manifestations of meningeal irritation. They all recovered after a short illness without sequelae. The cerebrospinal fluid showed a well marked increase in lymphocytes but yielded sterile cultures. Recognized conditions which may cause similar reactions in the cerebrospinal fluid, such as tuberculous meningitis or poliomyelitis, could be excluded.
In 1935 Rivers and Scott1 isolated from the cerebrospinal fluid of two such cases a filtrable virus which has
LYMPHOCYTIC CHORIOMENINGITIS AS A SYSTEMIC DISEASE. Ann Intern Med. ;16:1023–1026. doi: 10.7326/0003-4819-16-5-1023
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Published: Ann Intern Med. 1942;16(5):1023-1026.
CNS Infections, Infectious Disease, Neurology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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