ROBERT B. NYE, M.D., F.A.C.P.; CHARLES W. SEMISCH III, M.D.; LOUIS MERVES, M.D.
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The etiological agent of epidemic cerebrospinal meningitis, the meningococcus, was first described in 1887 by Weichselbaum. Gwyn1 demonstrated the meningococcus in the blood stream. W. W. Herrick, who has had a very extensive experience with meningococcic infections, divided the infection into three stages, viz: (1) local invasion of the upper respiratory tract, (2) invasion of the blood stream, (3) metastatic localization. It is the consensus of opinion at present2 that in the pathogenesis of epidemic cerebrospinal meningitis, the pathway of infection is via blood stream rather than by direct extension from the nasopharynx, and that the process may terminate at
NYE RB, SEMISCH CW, MERVES L. CHRONIC MENINGOCOCCEMIA COMPLICATED BY ACUTE ENDOCARDITIS*. Ann Intern Med. 1942;16:1245–1252. doi: https://doi.org/10.7326/0003-4819-16-6-1245
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Published: Ann Intern Med. 1942;16(6):1245-1252.
Cardiology, Endocarditis, Infectious Disease, Multi-Organ Failure and Sepsis, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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