T. J. FATHERREE, M.D., F.A.C.P.; CECIL HURST, M.D.
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The term intermittent claudication was first used in 1831 by the French veterinarian Bouley1 to describe a condition of limping in the horse, developing after a short period of exercise, recovering rapidly with rest, and found to be associated with an obliterative disease affecting the main artery of the leg. Subsequently several investigators, notably Brodie,2 Charcot,3 and Erb,4 observed and described a similar condition in human patients, and as a result of their observations it was established that the usual anatomical defect associated with this condition is arterial occlusion and that the limping or lameness results most commonly from pain.
FATHERREE TJ, HURST C. INTERMITTENT CLAUDICATION: ITS TREATMENT WITH AN INSULIN-FREE, DEPROTEINATED PANCREATIC EXTRACT (DEPROPANEX)1. Ann Intern Med. 1942;17:325–332. doi: 10.7326/0003-4819-17-2-325
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Published: Ann Intern Med. 1942;17(2):325-332.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism, Gastroenterology/Hepatology.
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