B. A. HOUSSAY; E. BRAUN-MENENDEZ; L. DEXTER
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Tigerstedt and Bergmann1 described a pressor substance, renin, which is found in kidney but not in other organs and which has a prolonged pressor effect when injected intravenously. Kohlstaedt and Page2 showed that purified renin had no vasoconstrictor action when perfused through a rabbit's ear but that it became active when mixed with blood colloids. This has been corroborated by others.3 Braun-Menendez, Fasciolo, Leloir, and Muñoz4, 5, 3 identified a pressor and vasoconstrictor substance, which they called hypertensin, in the venous blood of ischemic kidneys and showed that the same substance could be obtained in vitro by incubation of renin
HOUSSAY BA, BRAUN-MENENDEZ E, DEXTER L. THE DESTRUCTION AND ELIMINATION OF RENIN IN THE DOG1. Ann Intern Med. ;17:461–473. doi: 10.7326/0003-4819-17-3-461
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Published: Ann Intern Med. 1942;17(3):461-473.
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