W. H. B.
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Less than eight years ago Domagk published his initial report on the striking effects of the brick-red dye prontosil in experimental hemolytic streptococcal infections in mice. Shortly thereafter it was found that a relatively simple chemical compound, sulfanilamide, or para-amino-benzene-sulfonamide, was the active constituent of prontosil. These discoveries marked the dawn of a new era in the chemotherapy of bacterial infections. As a result a stupendous amount of experimental work has been carried out and the medical literature has been flooded with articles on the effects of the various sulfonamides in the treatment of infectious diseases. Many new compounds have
B. WH. SULFADIAZINE. Ann Intern Med. 1942;17:1029–1032. doi: 10.7326/0003-4819-17-6-1029
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Published: Ann Intern Med. 1942;17(6):1029-1032.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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