DAVID I. MACHT, M.D., F.A.C.P.
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At first engaging the attention primarily of physiologists and hematologists, the study1, 2, 3 of heparin was soon taken up also by biochemists, who of recent years have succeeded largely in unraveling its complicated chemical structure. More recently, heparin has acquired a practical significance through the work of clinical investigators who discerned its potentialities as a therapeutic agent. Indeed, Howell and McDonald4 had suggested such clinical applications of heparin, but its actual value in medical practice was not demonstrated until the painstaking investigations of American, Canadian and Swedish scientists were well under way. It is far beyond the scope
MACHT DI. EXPERIMENTAL STUDIES ON HEPARIN AND ITS INFLUENCE ON TOXICITY OF DIGITALOIDS, CONGO RED, COBRA VENOM AND OTHER DRUGS1. Ann Intern Med. ;18:772–791. doi: 10.7326/0003-4819-18-5-772
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Published: Ann Intern Med. 1943;18(5):772-791.
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