FRED W. ELLIS, PH.D.; JOHN C. KRANTZ JR., PH.D.
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Sorbitol was introduced into therapeutics in Europe under the name of "Sionin" by Thannhauser and Meyer1 in 1929. Since that time various workers have investigated its value as a substitute for carbohydrate in the diabetic diet with no consistent findings. Reinwein2 administered sorbitol to diabetics and observed an increase in the respiratory quotient but no rise in blood sugar. On the other hand, Roche and Raybaud3 observed no increase in the respiratory quotient, and Donhoffer and Donhoffer4 reported a rise in blood sugar after giving sorbitol to diabetic patients.
Kaufmann5 reported that sorbitol exhibited a protein-sparing action and was useful
ELLIS FW, KRANTZ JC. SUGAR ALCOHOLS XXIV. THE METABOLISM OF SORBITOL IN DIABETES*. Ann Intern Med. 1943;18:792–796. doi: https://doi.org/10.7326/0003-4819-18-5-792
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Published: Ann Intern Med. 1943;18(5):792-796.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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