R. GARFIELD SNYDER, M.D.; WILLARD HAYWOOD SQUIRES, M.D.; JOHN WILFRID FORSTER, M.D.; CORNELIUS HORACE TRAEGER, M.D.
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This study was to determine (1) the toxicity and (2) the therapeutic value of treatment with massive doses of vitamin D. The dosage used varied from 100,000 to 500,000 units daily. The average dose was 200,000 to 300,000 units. Within the limits of this dosage, in over five years, no deaths occurred and no evidence of serious toxicity was observed. No definite increase in the calcification of the blood vessels, as proved by roentgenograms, occurred, nor were there any evidences of stone formations in the kidney or gall-bladder or recalcification of bones. A few cases developed mild toxic symptoms such
SNYDER RG, SQUIRES WH, FORSTER JW, et al. TREATMENT OF TWO HUNDRED CASES OF CHRONIC ARTHRITIS WITH MASSIVE DOSES OF VITAMIN D PREPARED BY THE WHITTIER METHOD. Ann Intern Med. 1943;19:125–126. doi: 10.7326/0003-4819-19-1-125_2
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Published: Ann Intern Med. 1943;19(1):125-126.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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