CHARLES LEROY STEINBERG, M.D.
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The therapy of primary fibrositis has been most unsatisfactory, and there is no unanimity of opinion regarding it. Previous communications have called attention to the similarity in the pathologic lesions between so-called nutritional muscular dystrophy and primary fibrositis. Mackenzie and McCollum have shown that the development of nutritional muscular dystrophy is accompanied by an increase in urinary creatine excretion, and improvement by decrease in urinary creatine.
Creatine excretion studies were done on 15 cases of primary fibrositis by the Folin microchemical method. After tocopherol therapy these studies were repeated on 13 cases. The creatine excretion was increased in all cases
STEINBERG CL. THE TOCOPHEROLS (VITAMIN E) IN THE TREATMENT OF PRIMARY FIBROSITIS. Ann Intern Med. ;19:136–139. doi: 10.7326/0003-4819-19-1-136
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Published: Ann Intern Med. 1943;19(1):136-139.
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