CECIL JAMES WATSON, M.D., F.A.C.P.; JOHN A. LAYNE, M.D.
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In previous communications,1, 2 one of us (C. J. W.) pointed out that the Ellinger-Dojmi color reaction3 is due to urorosein, and that porphyrin, although capable of yielding color if present in sufficient amount, was not the source of the positive reactions encountered in urine samples from a variety of conditions, including pellagra. Beckh, Ellinger and Spies4 had employed the Ellinger-Dojmi reaction for the quantitative estimation of porphyrin in the urine. These investigators reported marked increases of porphyrin in a series of pellagra urines. They stated, moreover, that the administration of nicotinic acid was followed by a prompt fall in
WATSON CJ, LAYNE JA. STUDIES OF URINARY PIGMENTS IN PELLAGRA AND OTHER PATHOLOGICAL STATES. I. CLINICAL OBSERVATIONS*. Ann Intern Med. 1943;19:183–199. doi: https://doi.org/10.7326/0003-4819-19-2-183
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Published: Ann Intern Med. 1943;19(2):183-199.
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