JOHN A. LAYNE, M.D.; CECIL JAMES WATSON, M.D., F.A.C.P.
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In the preceding paper1 and in previous communications2, 3 it has been shown that the Beckh-Ellinger-Spies (B.E.S.) test4 is due to urorosein and that positive reactions are correlated in all instances with positive Nencki-Sieber (N.S.) tests for urorosein. Distinct increases of coproporphyrin were noted in alcoholic,2 but not in endemic pellagra.1, 3 Even in the former, the amounts of porphyrin were insufficient to be productive of color in the B.E.S. test. In order to study the effect of nicotinic acid in the absence of complicating factors such as alcoholism or other coexisting disease, the following studies were carried out in
LAYNE JA, WATSON CJ. STUDIES OF URINARY PIGMENTS IN PELLAGRA AND OTHER PATHOLOGICAL STATES. II. THE EXCRETION OF PORPHYRIN AND THE UROROSEIN REACTION IN DOGS WITH EXPERIMENTAL BLACKTONGUE1. Ann Intern Med. ;19:200–205. doi: 10.7326/0003-4819-19-2-200
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Published: Ann Intern Med. 1943;19(2):200-205.
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