ROY R. KRACKE, M.D.; BYRON J. HOFFMAN, M.D.
The presence of any intravascular mechanism that destroys red cells in excess of bone marrow compensation results in an anemia of the hemolytic type. Any classification of the hemolytic anemias is difficult because of the large number and wide variety of agents that can destroy red cells. Among such agents are bacterial and parasitic infections, drugs, chemicals, animal poisons, and occasionally red cell destruction occurs as an allergic phenomenon as observed in sensitivity to the bean Vicia fava or the pollen of its flower. Chronic familial hemolytic icterus with spherocytosis, increased fragility of the red cells to hypotonic saline solutions
KRACKE RR, HOFFMAN BJ. CHRONIC HEMOLYTIC ANEMIA WITH AUTOAGGLUTINATION AND HYPERGLOBULINEMIA; REPORT OF A FATAL CASE*. Ann Intern Med. 1943;19:673–684. doi: https://doi.org/10.7326/0003-4819-19-4-673
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Published: Ann Intern Med. 1943;19(4):673-684.
Hematology/Oncology, Red Cell Disorders.
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