JULES C. ABELS, M.D.; IRVING M. ARIEL, M.D.; HELEN T. MURPHY, PH.D.; GEORGE T. PACK, M.D.; C. P. RHOADS, M.D., F.A.C.P.
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In a previous investigation the livers of patients with gastrointestinal cancer were found to have abnormally high concentrations of fat and probably low concentrations of glycogen.1 This may be of clinical significance because, from the evidence, these changes render the liver abnormally susceptible to injury.2 The physiological effects of these two constituents may be interrelated, as suggested by the fact that the livers of individuals exposed to several hepatotoxins are not damaged when considerable amounts of glucose are administered.3 This effect apparently is not due simply to the increased amounts of hepatic glycogen deposited, but to the fact that
ABELS JC, ARIEL IM, MURPHY HT, PACK GT, RHOADS CP. METABOLIC STUDIES IN PATIENTS WITH CANCER OF THE GASTROINTESTINAL TRACT. IX. EFFECTS OF DIETARY CONSTITUENTS UPON THE CHEMICAL COMPOSITION OF THE LIVER, ESPECIALLY IN PATIENTS WITH GASTROINTESTINAL CANCER1. Ann Intern Med. ;20:580–589. doi: 10.7326/0003-4819-20-4-580
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© 2019
Published: Ann Intern Med. 1944;20(4):580-589.
DOI: 10.7326/0003-4819-20-4-580
Gastroenterology/Hepatology, Gastrointestinal Cancer, Hematology/Oncology, Liver Disease.