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Case Reports |1 August 1944

FATAL AGRANULOCYTOSIS FOLLOWING THE INTRAPERITONEAL IMPLANTATION OF SULFANILAMIDE CRYSTALS1

WILLIAM R. ARROWSMITH, M.D.; BARBARA BINKLEY, M.D.; CARL V. MOORE, M.D., F.A.C.P.

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
Paragraph127704*Received for publication May 2, 1943.
Paragraph127706From the Department of Internal Medicine and the Department of Pathology, Washington University Medical School, and from Barnes Hospital, St. Louis, Missouri.
Paragraph127708†Research Fellow of the American College of Physicians at the time these observations were made; now 1st Lt. MC, AUS. This article was completed before the author entered military service.
Paragraph127710‡We are indebted to Dr. Glover H. Copher for permission to report this case.
  • Paragraph127704*Received for publication May 2, 1943.
  • Paragraph127706From the Department of Internal Medicine and the Department of Pathology, Washington University Medical School, and from Barnes Hospital, St. Louis, Missouri.
  • Paragraph127708†Research Fellow of the American College of Physicians at the time these observations were made; now 1st Lt. MC, AUS. This article was completed before the author entered military service.
  • Paragraph127710‡We are indebted to Dr. Glover H. Copher for permission to report this case.
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Abstract

Comparatively few severe toxic reactions have resulted from the local use of sulfonamide drugs, presumably because relatively small amounts are placed in the tissues and because excretion is prompt.1 It has been demonstrated that with the dosages used in local application there is only temporary appearance of the drug in the blood.2, 3 The few severe reactions which have been described relate chiefly to the production of hepatic damage. Watson and Spink4 reported fatal hepatitis in two individuals who had received sulfanilamide by intra-peritoneal implantation, and Jackson and Coller3 observed nine instances of jaundice in a group of 62 patients

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ARROWSMITH WR, BINKLEY B, MOORE CV. FATAL AGRANULOCYTOSIS FOLLOWING THE INTRAPERITONEAL IMPLANTATION OF SULFANILAMIDE CRYSTALS1. Ann Intern Med. ;21:323–329. doi: 10.7326/0003-4819-21-2-323

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Published: Ann Intern Med. 1944;21(2):323-329.

DOI: 10.7326/0003-4819-21-2-323

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