F. B. CLARE; C. H. CRESS; E. GELLHORN
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Although leukocytosis has often been linked with the excitation of autonomic centers and the secretion of epinephrine (Müller,1 Hoff2) actual proof for this mechanism is rather inadequate. Walterhöfer3 showed that injection of epinephrine was followed by a neutrophilic leukocytosis which he attributed to the action of epinephrine on the bone marrow (cf. also Schön4). Borchardt5 likewise observed leukocytosis after epinephrine, but the physiological evaluation of these experiments is doubtful since this effect occurs only after administration of large doses of epinephrine and since similar effects may be obtained also after the injection of parasympathetic stimulants such as pilocarpin and choline.
CLARE FB, CRESS CH, GELLHORN E. LEUKOCYTOSIS AND THE SYMPATHETICO-ADRENAL SYSTEM1. Ann Intern Med. ;21:653–661. doi: 10.7326/0003-4819-21-4-653
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Published: Ann Intern Med. 1944;21(4):653-661.
Adrenal Disorders, Endocrine and Metabolism.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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