DOUGLAS DONALD, M.D., F.A.C.P.; RICHARD E. WUNSCH, M.D.
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Acute hemolytic anemia resulting from the use of sulfonamides has been frequently reported. Long, Haviland, Edwards and Bliss,1 in a large series, noted its occurrence in 1.8 per cent of cases following the administration of sulfanilamide and in 0.6 per cent after sulfapyridine. This toxic effect was not seen with sulfathiazole.
Rothstein and Cohn,2 however, have recently reported one case, and Bunim and Israel3 two cases following sulfathiazole.
Sulfadiazine has been considered innocuous as far as the hematopoietic system is concerned. Mild anemias may occur, but to date no case of hemolytic anemia following its use has been reported. For
DONALD D, WUNSCH RE. ACUTE HEMOLYTIC ANEMIA WITH TOXIC HEPATITIS CAUSED BY SULFADIAZINE; REPORT OF A CASE1. Ann Intern Med. ;21:709–711. doi: 10.7326/0003-4819-21-4-709
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Published: Ann Intern Med. 1944;21(4):709-711.
Emergency Medicine, Gastroenterology/Hepatology, Hematology/Oncology, Liver Disease, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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